Conserved RNA secondary structures promote alternative splicing
نویسندگان
چکیده
منابع مشابه
Conserved RNA secondary structures promote alternative splicing.
Pre-mRNA splicing is carried out by the spliceosome, which identifies exons and removes intervening introns. Alternative splicing in higher eukaryotes results in the generation of multiple protein isoforms from gene transcripts. The extensive alternative splicing observed implies a flexibility of the spliceosome to identify exons within a given pre-mRNA. To reach this flexibility, splice-site s...
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In higher eukaryotes, alternative splicing is usually regulated by protein factors, which bind to the pre-mRNA and affect the recognition of splicing signals. There is recent evidence that the secondary structure of the pre-mRNA may also play an important role in this process, either by facilitating or hindering the interaction with factors and small nuclear ribonucleoproteins (snRNPs) that reg...
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ژورنال
عنوان ژورنال: RNA
سال: 2008
ISSN: 1355-8382
DOI: 10.1261/rna.1069408